ea0044p166 | Neuroendocrinology and pituitary | SFEBES2016
Udeh-Momoh Chinedu
, Spiga Francesca
, Waite Eleanor
, Thomson Fiona
, Lightman Stafford
Actions of the stress hormone, glucocorticoid (GC), are essential for the modulation of implicated biological processes such as synaptic transmission. In disease paradigms that feature a hormone hyper-secretion phenotype (e.g. neurocognitive disorders), the normalcy of receptor signaling is compromised.The pro-cognate role of Glucocorticoid receptor (GR) inhibition via hormone analogues bearing anti-glucocorticoid properties is well described. A key exam...